By Taotao Zou

This thesis makes a speciality of the advance of gold- and non-classical platinum-based anti-cancer brokers that show distinctively diversified anti-cancer mechanisms in comparison to the generally used cisplatin. those steel complexes include N-heterocyclic carbene (NHC) ligands that are in a position to shape robust M-C(NHC) bonds, conferring excessive balance and favorable lipophilicity, reactivity and binding specificity of steel complexes on biomolecules. the writer demonstrates major advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. distinct chemical synthesis, in vitro and/or in vivo anti-cancer actions are essentially offered together with: (i) a category of Au(III) complexes containing a hugely fluorescent N^N^N ligand and NHC ligand that at the same time act as fluorescent thiol “switch-on” probes and anti-cancer brokers; (ii) a dinuclear gold(I) complicated with a combined diphosphine and bis(NHC) ligand showing favorable balance and displaying major inhibition of tumor development in self sufficient mice types without observable negative effects; and (iii) a panel of reliable luminescent cyclometalated platinum(II) complexes displaying excessive specificity to localize to the endoplasmic reticulum (ER) area, inducing ER pressure and telephone apoptosis. those works spotlight the scientific capability that gold and platinum complexes supply for melanoma treatment.

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Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II): Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors ... Reticulum Targeting Agents (Springer Theses) by Taotao Zou


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